Every subject underwent a medical and a psychiatric interview, which included the Mini international neuropsychiatry interview 5.0 (M. Severity assessment of SZ patients was determined with the positive and negative syndrome scale (PANSS) for SZ and the Clinical Global Impression Scale (CGI-S) [].

Subjects performed an N-back task, a WM paradigm that manipulates the number of items to be stored in memory.

In healthy subjects, P300 amplitude was highest in the low WM load condition, and lowest in both the attentional control condition and the high WM load condition.

Neuroinhibition is suggested as an overarching theoretical mechanism for P300, which is elicited when stimulus detection engages memory operations.

(2007) Updating P300: An Integrative Theory of P3a and P3b. has been cited by the following article: Applying Item Response Theory Methods to Improve the Measurement of Fatigue in a Clinical Trial of Rheumatoid Arthritis Patients Treated with Secukinumab* Mark Kosinski, Jakob B.

There was also a control condition (0-back), in which the subject had to recognize a specific digit -zero- when it appeared on the screen.

Subjects had to distinguish between targets and non-targets, by pressing two buttons localized in a response palette.from the face) located in the center of a black background screen in a 21' CRT monitor.Inter stimulus interval (ISI) were 1.7 sec in all the conditions studied.In contrast, SZs evidenced low P300 amplitude in all conditions.A significant between group difference in P300 amplitude was evidenced only at the low WM load condition (1 -back), being smaller in SZs. Thus, the study of WM mechanisms and their impairments in SZ might contribute to unveil some of the underlying affected mechanisms in this disease.The aim of this study was to determine the dependency of the P300 component on WM load in a sample of SZ subjects.