CAC not only provides information regarding cardiovascular risk, but it can also be used to track progression of atherosclerosis over time [24-28].

It has been suggested that a synergistic effect exists between statin therapy and AGE in retarding progression of CAC.

online dating ron beadenkopf-25online dating ron beadenkopf-41

For example, in one observational study using non-contrast CT, 123 persons with hypercholesterolemia were followed [29].

This study showed that patients on placebo (with statin baseline therapy) progressed at a rate of 22.2% per year, and the addition of AGE reduced CAC progression to 7.5%, a reduction of over 66%.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Objective: No study of sufficient power to date has evaluated the ability of AGE to inhibit vascular calcification, a marker of plaque formation in human coronary arteries.

Received date: September 10, 2015; Accepted date: September 21, 2015; Published date: October 05, 2015 Citation: Hom C, Luo Y, Budoff MJ (2015) The Effects of Aged Garlic Extract on Coronary Artery Calcification Progression. Since AGE has been shown to have several potential anti-atherosclerotic properties, including stimulation of microcirculation in peripheral arteries, it was chosen as the agent of study to evaluate its ability to inhibit progression of coronary atherosclerosis.

Visit for more related articles at Journal of Nutrition & Food Sciences Background: Aged Garlic Extract (AGE) has been shown to lower LDL, reduce the progression of coronary atherosclerosis, improve vascular function, and have a favorable effect on oxidative biomarkers.Unlike other noninvasive modalities used to diagnose coronary artery disease (CAD) by focusing on physiologic consequences of coronary obstruction, CAC represents an anatomic measure of plaque burden [19].There is general agreement that CAC provides a useful measure of atherosclerosis for population studies, and is the most predictive method for ascertaining risk in an asymptomatic cohort.AGE has effects on coronary atherosclerosis by preventing smooth muscle cell transformation and proliferation, preventing entry of lipids into arterial walls and macrophages, and also directly suppressing atherosclerosis [7,8].AGE has been shown to also have beneficial effects on arterial function by inhibiting endothelial cell damage, transforming smooth muscles cells, and inhibiting the damage of nitric oxide synthesis [9,10].Previous studies have shown that the progression of CAC, defined as clinically significant when the rate of change exceeds 15% per year based upon clinical outcomes studies, may provide incremental prognostic information beyond that provided by the baseline calcium score itself.