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Just at a time when checkpoints should start getting more predictable, the field seems to be ripe for fresh surprises of all kinds.
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It has a combo of Imfinzi with an in-house CTLA-4 checkpoint dubbed tremelimumab in the MYSTIC study that will read out soon for lung cancer.
Analysts are waiting eagerly to see if it can beat out the competition, or get sidelined by some well-known toxicity concerns. Bristol-Myers Squibb started as the dominant player in PD-(L)1, then got checked by a surging Merck when it made the wrong clinical move on non-small cell lung cancer.
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Over the last few months it hasn’t been unusual to see new combination studies being announced on a daily basis, matching one of the 5 approved PD-(L)1 checkpoint drugs with another cancer therapy. And some of the big players are happy to contribute their drug to studies sponsored by others looking to advance a pilot Phase I/II exploratory study.