HNF1B Loss Exacerbates the Development of Chromophobe Renal Cell Carcinomas. Yin Q, Hung SC, Wang L, Lin W, Fielding JR, Rathmell WK, Khandani AH, Woods ME, Milowsky MI, Brooks SA, Wallen EM, Shen D. PMID: 28256615, PMCID: PMC5335708, PII: srep43356, DOI: 10.1038/srep43356, ISSN: 2045-2322. Strategies to overcome therapeutic resistance in renal cell carcinoma. Kasoji SK, Chang EH, Mullin LB, Chong WK, Rathmell WK, Dayton PA. PMID: 27108841, PMCID: PMC4871728, PII: nrneph.2016.58, DOI: 10.1038/nrneph.2016.58, ISSN: 1759-507X. Variation in chromatin accessibility in human kidney cancer links H3K36 methyltransferase loss with widespread RNA processing defects. Gallagher SA, Smith AB, Matthews JE, Potter CW, Woods ME, Raynor M, Wallen EM, Rathmell WK, Whang YE, Kim WY, Godley PA, Chen RC, Wang A, You C, Barocas DA, Pruthi RS, Nielsen ME, Milowsky MI. PMID: 23434424, PMCID: PMC4058502, PII: S1078-1439(12)00425-5, DOI: 10.1016/j.urolonc.20, ISSN: 1873-2496. PMID: 19576797, PII: S1078-1439(09)00134-3, DOI: 10.1016/j.urolonc.20, ISSN: 1873-2496. PMID: 20154618, PMCID: PMC2906148, DOI: 10.1097/CCO.0b013e328337a5d2, ISSN: 1531-703X. Renal cell carcinoma: where will the state-of-the-art lead us? Identifying m RNA targets of micro RNA dysregulated in cancer: with application to clear cell Renal Cell Carcinoma. Benders AA, Tang W, Middeldorp JM, Greijer AE, Thorne LB, Funkhouser WK, Rathmell WK, Gulley ML. PMID: 20596845, PMCID: PMC2811562, DOI: 10.1007/s12105-009-0148-8, ISSN: 1936-0568. PMID: 20648240, PMCID: PMC2906134, DOI: 10.1517/17460441.3.3.311, ISSN: 1746-045X. VHL inactivation in renal cell carcinoma: implications for diagnosis, prognosis and treatment. Hickey MM, Lam JC, Bezman NA, Rathmell WK, Simon MC. PMID: 17992257, PMCID: PMC2066197, DOI: 10.1172/JCI32614, ISSN: 0021-9738. PMID: 16552243, PII: 00001622-200605000-00013, DOI: 10.1097/010000219260.60714.c4, ISSN: 1531-703X. Molecularly targeted therapy in renal cell carcinoma. In vitro and in vivo models analyzing von Hippel-Lindau disease-specific mutations. Phase II trial of 5-fluorouracil and leucovorin in combination with interferon-alpha and interleukin-2 for advanced renal cell cancer. Associations between Tumor Vascularity, Vascular Endothelial Growth Factor Expression and PET/MRI Radiomic Signatures in Primary Clear-Cell-Renal-Cell-Carcinoma: Proof-of-Concept Study. A Pilot Clinical Study in Characterization of Malignant Renal-cell Carcinoma Subtype with Contrast-enhanced Ultrasound. 2017 Feb 2/20/2017; PMID: 28220033, PII: 15536, DOI: 10.18632/oncotarget.15536, ISSN: 1949-2553. PMID: 27861752, PMCID: PMC5222778, DOI: 10.1002/cncr.30314, ISSN: 1097-0142. Kidney cancer: Rest ASSUREd, much can be learned from adjuvant studies in renal cancer. Haake SM, Li J, Bai Y, Kinose F, Fang B, Welsh EA, Zent R, Dhillon J, Pow-Sang JM, Chen YA, Koomen JM, Rathmell WK, Fishman M, Haura EB. Kishton RJ, Barnes CE, Nichols AG, Cohen S, Gerriets VA, Siska PJ, Macintyre AN, Goraksha-Hicks P, de Cubas AA, Liu T, Warmoes MO, Abel ED, Yeoh AE, Gershon TR, Rathmell WK, Richards KL, Locasale JW, Rathmell JC. PMID: 27076078, PMCID: PMC4832577, PII: S1550-4131(16)30111-5, DOI: 10.1016/20, ISSN: 1932-7420. PMID: 25079317, PMCID: PMC4170219, PII: nature13480, DOI: 10.1038/nature13480, ISSN: 1476-4687. PMID: 25079552, PMCID: PMC4231481, PII: nature13385, DOI: 10.1038/nature13385, ISSN: 1476-4687. Roadmap for the development of the University of North Carolina at Chapel Hill Genitourinary Onco Logy Database--UNC GOLD. Rasmussen NR, Debebe Z, Wright TM, Brooks SA, Sendor AB, Brannon AR, Hakimi AA, Hsieh JJ, Choueiri TK, Tamboli P, Maranchie JK, Hinds P, Wallen EM, Simpson C, Norris JL, Janzen WP, Rathmell WK. PMID: 25542006, PMCID: PMC4277431, PII: PONE-D-14-13817, DOI: 10.1371/0116101, ISSN: 1932-6203. PMID: 22014593, PII: S0090-4295(11)02320-X, DOI: 10.1016/j.urology.20, ISSN: 1527-9995. PMID: 21470103, PII: BSP/CCP/E-Pub/0035, ISSN: 2212-3938. Kurpad R, Kim W, Rathmell WK, Godley P, Whang Y, Fielding J, Smith L, Pettiford A, Schultz H, Nielsen M, Wallen EM, Pruthi RS. Pruthi RS, Nielsen M, Heathcote S, Wallen EM, Rathmell WK, Godley P, Whang Y, Fielding J, Schultz H, Grigson G, Smith A, Kim W. PMID: 20089114, PII: BJU9101, DOI: 10.1111/j.1464-410X.2009.09101.x, ISSN: 1464-410X. Emerging molecular classification in renal cell carcinoma: implications for drug development. Epstein-Barr virus latent membrane protein 1 is not associated with vessel density nor with hypoxia inducible factor 1 alpha expression in nasopharyngeal carcinoma tissue. Wright TM, Brannon AR, Gordan JD, Mikels AJ, Mitchell C, Chen S, Espinosa I, van de Rijn M, Pruthi R, Wallen E, Edwards L, Nusse R, Rathmell WK. PMID: 19448672, PMCID: PMC2771692, PII: onc2009116, DOI: 10.1038/onc.2009.116, ISSN: 1476-5594. PMID: 19216840, PMCID: PMC2873025, ISSN: 1534-6269. Gordan JD, Lal P, Dondeti VR, Letrero R, Parekh KN, Oquendo CE, Greenberg RA, Flaherty KT, Rathmell WK, Keith B, Simon MC, Nathanson KL. PMID: 19061835, PMCID: PMC2621440, PII: S1535-6108(08)00366-8, DOI: 10.1016/20, ISSN: 1878-3686. PMID: 18391630, PII: 00001622-200805000-00011, DOI: 10.1097/CCO.0b013e3282f9782b, ISSN: 1531-703X. Using Molecular Biology to Develop Drugs for Renal Cell Carcinoma. Von Hippel-Lindau mutation in mice recapitulates Chuvash polycythemia via hypoxia-inducible factor-2alpha signaling and splenic erythropoiesis. Gollob JA, Rathmell WK, Richmond TM, Marino CB, Miller EK, Grigson G, Watkins C, Gu L, Peterson BL, Wright JJ. PMID: 17414642, PII: 00001622-200705000-00011, DOI: 10.1097/CCO.0b013e3280ad4388, ISSN: 1040-8746. Biological aspects and binding strategies of vascular endothelial growth factor in renal cell carcinoma.

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Haake SM, Brooks SA, Welsh E, Fulp WJ, Chen DT, Dhillon J, Haura E, Sexton W, Spiess PE, Pow-Sang J, Rathmell WK, Fishman M. Primary renal cell carcinoma: relationship between 18F-FDG uptake and response to neoadjuvant sorafenib.

Patients with Clear Code34-identified molecular subtypes of clear cell renal cell carcinoma represent unique populations with distinct comorbidities. 2015 Nov 11/3/2015; PMID: 26546482, PII: S1078-1439(15)00480-9, DOI: 10.1016/j.urolonc.20, ISSN: 1873-2496.

Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead. Hu Z, Brooks SA, Dormoy V, Hsu CW, Hsu HY, Lin LT, Massfelder T, Rathmell WK, Xia M, Al-Mulla F, Al-Temaimi R, Amedei A, Brown DG, Prudhomme KR, Colacci A, Hamid RA, Mondello C, Raju J, Ryan EP, Woodrick J, Scovassi AI, Singh N, Vaccari M, Roy R, Forte S, Memeo L, Salem HK, Lowe L, Jensen L, Bisson WH, Kleinstreuer N. PMID: 26106137, PMCID: PMC4492067, PII: bgv036, DOI: 10.1093/carcin/bgv036, ISSN: 1460-2180. A tale of two cancers: Complete genetic analysis of chromophobe renal cell carcinoma contrasts with clear cell renal cell carcinoma. Sendor AB, Hacker KE, Chen S, Corona AL, Sen O, Chiang DY, Snavely A, Rogers AB, Montgomery SA, Rathmell WK, Mc Ree AJ. PMID: 25844041, PMCID: PMC4383253, DOI: 10.2147/GICTT.

Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: focus on the cancer hallmark of tumor angiogenesis. Von Hippel-Lindau status influences phenotype of liver cancers arising from PTEN loss.

Chang EH, Chong WK, Kasoji S, Dayton PA, Rathmell WK.

Management of Indeterminate Cystic Kidney Lesions: Review of Contrast-Enhanced Ultrasound as a Diagnostic Tool. 2015 Oct 10/16/2015; PMID: 26483268, PII: S0090-4295(15)00938-3, DOI: 10.1016/j.urology.20, ISSN: 1527-9995.

Context-dependent role for chromatin remodeling component PBRM1/BAF180 in clear cell renal cell carcinoma. Deep exploration of the immune infiltrate and outcome prediction in testicular cancer by quantitative multiplexed immunohistochemistry and gene expression profiling. Management and outcomes of patients with renal medullary carcinoma: a multicentre collaborative study. 2016 Nov 11/8/2016; PMID: 27860149, DOI: 10.1111/bju.13705, ISSN: 1464-410X. Broad targeting of angiogenesis for cancer prevention and therapy. Linehan WM, Spellman PT, Ricketts CJ, Creighton CJ, Fei SS, Davis C, Wheeler DA, Murray BA, Schmidt L, Vocke CD, Peto M, Al Mamun AA, Shinbrot E, Sethi A, Brooks S, Rathmell WK, Brooks AN, Hoadley KA, Robertson AG, Brooks D, Bowlby R, Sadeghi S, Shen H, Weisenberger DJ, Bootwalla M, Baylin SB, Laird PW, Cherniack AD, Saksena G, Haake S, Li J, Liang H, Lu Y, Mills GB, Akbani R, Leiserson MD, Raphael BJ, Anur P, Bottaro D, Albiges L, Barnabas N, Choueiri TK, Czerniak B, Godwin AK, Hakimi AA, Ho TH, Hsieh J, Ittmann M, Kim WY, Krishnan B, Merino MJ, Shaw KR, Reuter VE, Reznik E, Shelley CS, Shuch B, Signoretti S, Srinivasan R, Tamboli P, Thomas G, Tickoo S, Burnett K, Crain D, Gardner J, Lau K, Mallery D, Morris S, Paulauskis JD, Penny RJ, Shelton C, Shelton WT, Sherman M, Thompson E, Yena P, Avedon MT, Bowen J, Gastier-Foster JM, Gerken M, Leraas KM, Lichtenberg TM, Ramirez NC, Santos T, Wise L, Zmuda E, Demchok JA, Felau I, Hutter CM, Sheth M, Sofia HJ, Tarnuzzer R, Wang Z, Yang L, Zenklusen JC, Zhang J, Ayala B, Baboud J, Chudamani S, Liu J, Lolla L, Naresh R, Pihl T, Sun Q, Wan Y, Wu Y, Ally A, Balasundaram M, Balu S, Beroukhim R, Bodenheimer T, Buhay C, Butterfield YS, Carlsen R, Carter SL, Chao H, Chuah E, Clarke A, Covington KR, Dahdouli M, Dewal N, Dhalla N, Doddapaneni HV, Drummond JA, Gabriel SB, Gibbs RA, Guin R, Hale W, Hawes A, Hayes DN, Holt RA, Hoyle AP, Jefferys SR, Jones SJ, Jones CD, Kalra D, Kovar C, Lewis L, Li J, Ma Y, Marra MA, Mayo M, Meng S, Meyerson M, Mieczkowski PA, Moore RA, Morton D, Mose LE, Mungall AJ, Muzny D, Parker JS, Perou CM, Roach J, Schein JE, Schumacher SE, Shi Y, Simons JV, Sipahimalani P, Skelly T, Soloway MG, Sougnez C, Tam A, Tan D, Thiessen N, Veluvolu U, Wang M, Wilkerson MD, Wong T, Wu J, Xi L, Zhou J, Bedford J, Chen F, Fu Y, Gerstein M, Haussler D, Kasaian K, Lai P, Ling S, Radenbaugh A, Van Den Berg D, Weinstein JN, Zhu J, Albert M, Alexopoulou I, Andersen JJ, Auman JT, Bartlett J, Bastacky S, Bergsten J, Blute ML, Boice L, Bollag RJ, Boyd J, Castle E, Chen YB, Cheville JC, Curley E, Davies B, De Volk A, Dhir R, Dike L, Eckman J, Engel J, Harr J, Hrebinko R, Huang M, Huelsenbeck-Dill L, Iacocca M, Jacobs B, Lobis M, Maranchie JK, Mc Meekin S, Myers J, Nelson J, Parfitt J, Parwani A, Petrelli N, Rabeno B, Roy S, Salner AL, Slaton J, Stanton M, Thompson RH, Thorne L, Tucker K, Weinberger PM, Winemiller C, Zach LA, Zuna R, . Parfenov M, Pedamallu CS, Gehlenborg N, Freeman SS, Danilova L, Bristow CA, Lee S, Hadjipanayis AG, Ivanova EV, Wilkerson MD, Protopopov A, Yang L, Seth S, Song X, Tang J, Ren X, Zhang J, Pantazi A, Santoso N, Xu AW, Mahadeshwar H, Wheeler DA, Haddad RI, Jung J, Ojesina AI, Issaeva N, Yarbrough WG, Hayes DN, Grandis JR, El-Naggar AK, Meyerson M, Park PJ, Chin L, Seidman JG, Hammerman PS, Kucherlapati R, . PMID: 25313082, PMCID: PMC4217452, PII: 1416074111, DOI: 10.1073/pnas.1416074111, ISSN: 1091-6490. Integrated genomic characterization of papillary thyroid carcinoma. Racial difference in histologic subtype of renal cell carcinoma. Receptor tyrosine kinase-like orphan receptor 2 (Ror2) expression creates a poised state of Wnt signaling in renal cancer. FDG-PET as a predictive biomarker for therapy with everolimus in metastatic renal cell cancer. Lockhart AC, Brose MS, Kim ES, Johnson DH, Peppercorn JM, Michels DL, Storm CD, Schuchter LM, Rathmell WK. PMID: 23530092, PMCID: PMC4525129, PII: JCO.20, DOI: 10.1200/JCO.20, ISSN: 1527-7755. Kapur P, Peña-Llopis S, Christie A, Zhrebker L, Pavía-Jiménez A, Rathmell WK, Xie XJ, Brugarolas J. PMID: 23333114, PMCID: PMC4674067, PII: S1470-2045(12)70584-3, DOI: 10.1016/S1470-2045(12)70584-3, ISSN: 1474-5488. Regulation of KLF4 turnover reveals an unexpected tissue-specific role of p VHL in tumorigenesis. Kim WY, Whang YE, Pruthi RS, Baggstrom MQ, Rathmell WK, Rosenman JG, Wallen EM, Goyal LK, Grigson G, Watkins C, Godley PA. PMID: 20022268, PII: S1078-1439(09)00293-2, DOI: 10.1016/j.urolonc.20, ISSN: 1873-2496. Tumor suppressive activity of prolyl isomerase Pin1 in renal cell carcinoma. Oosterwijk E, Rathmell WK, Junker K, Brannon AR, Pouliot F, Finley DS, Mulders PF, Kirkali Z, Uemura H, Belldegrun A.

Park IY, Chowdhury P, Tripathi DN, Powell RT, Dere R, Terzo EA, Rathmell WK, Walker CL. PMID: 27594515, DOI: 10.1080/19420862.2016.1228505, ISSN: 1942-0870. De Velasco G, Miao DD, Voss MH, Hakimi AA, Hsieh JJ, Tannir NM, Tamboli P, Appleman LJ, Rathmell WK, Van Allen E, Choueiri TK. Hacker KE, Fahey CC, Shinsky SA, Chiang YJ, Di Fiore JV, Jha DK, Vo AH, Shavit JA, Davis IJ, Strahl BD, Rathmell WK. Comprehensive Molecular Characterization of Papillary Renal-Cell Carcinoma. 2015 Nov 11/4/2015; PMID: 26536169, DOI: 10.1056/NEJMoa1505917, ISSN: 1533-4406. Clear Code34: a prognostic risk predictor for localized clear cell renal cell carcinoma. Characterization of HPV and host genome interactions in primary head and neck cancers. Physician and stakeholder perceptions of conflict of interest policies in oncology. Gameiro PA, Yang J, Metelo AM, Pérez-Carro R, Baker R, Wang Z, Arreola A, Rathmell WK, Olumi A, López-Larrubia P, Stephanopoulos G, Iliopoulos O. PMID: 23473032, PMCID: PMC4003458, PII: S1550-4131(13)00050-8, DOI: 10.1016/20, ISSN: 1932-7420. Ethical challenges: managing oncology drug shortages. Effects on survival of BAP1 and PBRM1 mutations in sporadic clear-cell renal-cell carcinoma: a retrospective analysis with independent validation. Whang YE, Armstrong AJ, Rathmell WK, Godley PA, Kim WY, Pruthi RS, Wallen EM, Crane JM, Moore DT, Grigson G, Morris K, Watkins CP, George DJ. PMID: 21396844, PII: S1078-1439(10)00299-1, DOI: 10.1016/j.urolonc.20, ISSN: 1873-2496. PMID: 22681671, PII: S0001-2998(12)00022-0, DOI: 10.1053/j.semnuclmed.20, ISSN: 1558-4623. Neoadjuvant docetaxel/estramustine prior to radical prostatectomy or external beam radiotherapy in high risk localized prostate cancer: a phase II trial.

Our goal is to identify strategies to improve the treatment of cancers dependent on hypoxia pathway activation, or better ways to detect these cancers earlier. Chang EH, Chong WK, Kasoji SK, Fielding JR, Altun E, Mullin LB, Kim JI, Fine JP, Dayton PA, Rathmell WK. PMID: 28793871, PMCID: PMC5551034, PII: 10.1186/s12882-017-0681-8, DOI: 10.1186/s12882-017-0681-8, ISSN: 1471-2369. PMID: 20185829, PMCID: PMC2857057, PII: M109.073924, DOI: 10.1074/jbc. Cowey CL, Amin C, Pruthi RS, Wallen EM, Nielsen ME, Grigson G, Watkins C, Nance KV, Crane J, Jalkut M, Moore DT, Kim WY, Godley PA, Whang YE, Fielding JR, Rathmell WK. PMID: 20159822, PMCID: PMC4525128, PII: JCO.20, DOI: 10.1200/JCO.20, ISSN: 1527-7755. Mack FA, Rathmell WK, Arsham AM, Gnarra J, Keith B, Simon MC. PMID: 12559177, PMCID: PMC4120823, PII: S1535610802002404, ISSN: 1535-6108. Yersinia pseudotuberculosis bacteremia and splenic abscess in a patient with non-insulin-dependent diabetes mellitus.